From Wiki Drugs

Fluoxetine is also Prozac, Fonteks, Ladose, Sarafem, Solaks (Fluoxetine) - medication, an antidepressant. White or almost white crystalline powder.

Despite the fact that in recent years on the pharmacological market many new antidepressants, fluoxetine currently occupies a leading position. So, there was issued about 26 million prescriptions for fluoxetine in the USA in 2006.

Pharmacological action

Fluoxetine - antidepressant, a derivative PROPYLAMINE belonging to a selective or selective serotonin reuptake inhibitors nerve endings, it has little effect on the seizure of noradrenalin and dopamine. The mechanism of action associated with selective blockade of neuronal serotonin reuptake in the CNS. Fluoxetine is a weak antagonist holino-, adreno-and histamine receptors. Unlike most antidepressants, fluoxetine, apparently, does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. It contributes to improve mood, reduces anxiety and stress, and eliminates dysphoria. Does not cause sedation. When you receive high therapeutic doses, it has practically no effect on the function of the cardiovascular and other systems.

Apply with different types of depression (especially depression, accompanied by fear). The usual dosage for adults - 20 mg / day (oral). After a few weeks increase the dosage to 20 mg per day. Maximum daily dosage - 80 mg. Persons aged and old prescribe a dosage of up to 60 mg per day. When single dosage (20 mg) taken in the morning, the two-fold - in the morning and afternoon.

Pharmacokinetics

The drug is well absorbed from the gastrointestinal tract. Poorly metabolized in the "first-pass liver. Eating does not affect the extent of absorption, although it may slow its speed. Maximum plasma concentrations are reached after 6-8 h. The equilibrium concentration in plasma is achieved only after continuous reception in a few weeks. Protein binding is 94.5%. It is easy to penetrate the BBB. It is metabolized in the liver by demethylation to form the main active metabolite norfluoksetina. The half-life of fluoxetine is 2-3 days, norfluoksetina - 7-9 days. It is excreted by the kidneys and 80% through the intestine - about 15%.

The drug is usually well tolerated. In connection with weak anticholinergic effect is is relatively rare cause constipation, dry mouth (in comparison with amitriptyline and other tricyclic antidepressants).

It may cause drowsiness, headache, nausea, vomiting, loss of appetite (has anoreksigennoy action).

Do not use the drug concurrently with MAO inhibitors, as well as within 14 days after the end of their reception. Not allowed alcohol intake.

Interesting facts

Prozac affects the sexual behavior of freshwater snails and oysters.

Medicine links

• Fluoxetine
• Sarafem