Sildenafil

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Sildenafil is the drug for increasing the potency. Trade name is Viagra. Sildenafil citrate is available in tablet form for 25, 50 and 100 mg, which contain, respectively, at 25, 50 and 100 mg of sildenafil citrate. Unlike other treatments for erectile dysfunction, which provide for injections into the penis or other medical procedures, sildenafil is a simple, convenient and easily used drug. Using sildenafil take one tablet before planned sexual intercourse.

The mechanism of action of Sildenafil

The drug increases the amount of blood flowing to the penis. This helps a man to call a natural erection. Sildenafil is effective only when a man experiences a natural sexual arousal, and when the sexual act is completed, the penis naturally returns to the relaxed state. In other words, sildenafil acts only on natural mechanisms of erection and this is its undeniable novelty and secret huge popularity.

How does Viagra in the clinical sense?

There conducted numerous experiments and tests of Viagra on volunteers with varying degrees of erectile dysfunction. As shown by tests, Viagra has a high efficiency. The effectiveness of Viagra in the first place depends on the degree of erectile dysfunction, as well as from its cause. For example, if the problem erection vascular dysfunction, the drug copes with its task. If the problem is in the venous drainage, the result of Viagra will be much worse.

Pharmacokinetics

TCmax after ingestion, fasting - 0,5-2 h, bioavailability - 25-60%. When you receive a greasy food Cmax decreased by 20-40% and is achieved through 1,5-3 h. The volume of distribution at steady state - 105 liters.

Indications

Erectile dysfunction of various etiologies (organic, psychogenic, mixed). Impotence. Treatment of pulmonary hypertension.

Contraindications

Hypersensitivity; simultaneous reception donor of nitric oxide or nitrates in any form. Viagra is used with caution in diseases of the heart, anatomical deformations of the penis, sickle cell anemia, multiple myeloma and leukemia.

Dosage

Take viagra orally, about 1 hour before planned sexual activity. Single viagra dose for adults - 50 mg 1 time per day. Given the efficacy and tolerability the dose may be increased to 100 mg or decreased to 25 mg. The maximum single viagra dose should be 100 mg. In patients with impaired liver or kidney function and elderly patients dose adjustment is required.

Side effects

Headache, "tides" of blood to the face, dizziness, dyspepsia, nasal congestion, visual disturbances (change in color of objects (blue / green), increased perception of light, violation of clarity of vision).

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